Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
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چکیده
منابع مشابه
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.
Germline loss-of-function mutations in the transcription factor signal transducer and activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function mutations in STAT3 are associated with large granular lymphocytic leukemic, myelodysplastic syndrome, and aplastic anemia. Recently, germline mutations in STAT3 have also been associated with autoimmune disease. Here,...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-09-602763